Wastewater in Tainan’s Science-based Industrial Park is mainly produced in the process of production. To investigate if the wastewater effluence in Science-based Industrial Park in Tainan complies with wastewater effluence standards, this study analyzes wastewater data collected by National Cheng Kung University. Then water quality index (WQI) are calculated and examined by means of comparing the above data with the standard of sewer and expected reduction agreement of the Science-based Park administration. This is for checking if they met the effluence standards. The Environment Protect Agency’s (EPA) wastewater effluence standards, based on Water Pollution Control Act and related time series profile are also consulted to assist examining the data.